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Nikalje, Anna Pratima
- Ultrasound-Promoted Green Synthesis and Pharmacological Screening of Some Novel 4-(3, 5-Diaryl Substituted)-4,5-Dihydro-1H-Pyrazol-1-yl) Benzene Sulfonamide
Authors
1 Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr.Rafiq Zakaria Campus, Rauza Bagh, P.B. No. 33 Aurangabad (M.S.) 431001, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1712-1716Abstract
A simple, efficient and green procedure has been developed for the synthesis of novel of 4-(3, 5-diarylsubstituted)-4,5- dihydro-1H-pyrazol-1-yl) benzene sulfonamides using ultrasonic irradiation. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times and milder conditions. A mixture of substituted prop-2-en-1-ones, 4-hydrazinylbenzenesulfonamide hydrochloride and hydrazine hydrate in ethanol and acetic acid was irradiated under ultrasound in an open vessel. The synthesized pyrazolines containing benzenesulphonamide group were evaluated for their anti-inflammatory activity using Carrageenan-induced rat hind paw oedema and have shown promising t anti-inflammatory activity.
Keywords
Green Synthesis, Ultrasound, Pyrazolines, Sulphonamides, Anti-Inflamatory Activity.
- Biocatalysis:A Brief Review
Authors
1 Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, PB No.33, Rouza Bagh, Aurangabad, 431001 (MS), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1355-1360Abstract
Bio catalysis underpins some of the oldest chemical transformations known to humans. Biocatalysis is the use of natural catalysts, such as protein enzymes to perform chemical transformations on organic compounds. Both enzymes that have been more or less isolated and enzymes still residing inside living cells are employed for this task. More than one hundred years ago, bio catalysis was employed to do chemical transformations on non-natural man-made organic compounds and the last 30 years have seen a substantial increase in the application of bio catalysis to produce fine chemicals, especially for the pharmaceutical industry. Here the author emphasizes on the various application of biocatalysts useful in the pharmaceutical industry.Keywords
Biocatalysis, Enzyme, Enzyme Synthesis.- Efficient One Pot Green Synthesis of 2-Aryl/Heteryl-Benzothiazoles as Anti-Inflammatory Agents
Authors
1 Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad-431001, MS, IN